A Brief Review: Advancement in the Synthesis of Amine through the Leuckart Reaction

This review presents a summary of reactions that take place during the “Leuckart-type reaction”. The significance of, as well recent advancements in, synthesis amines through simple and inexpensive methods using readily available raw materials is discussed. includes all catalytic noncatalytic involve Leuckart method. Recent studies have shown at least quarter C–N bond-forming in pharmaceutical industry are occur with support reductive amination. Recently, experimental conditions achieved excellent yields. reaction” technically associated Eschweiler–Clarke methylation. Compounds grouped accordance precept action. drugs affecting central nervous system, cardiovascular system gastrointestinal tract; anticancer drugs, antibiotics, antiviral antifungal drugs; anxiety; convulsant, biotic, HIV antidiabetic drugs. Therefore, this supports development Leuckart-type preparation nitrogenous compounds, their advancement other areas human development.